Regression of a Large Endometrio...
Endometriosis is defined as presence of endometrial glands and
stroma outside endomoetrium [1]. Ovarian endometriomas are
a common presentation of endometriosis. Surgery is universally
considered the first therapeutic approach for women with symptomatic
or enlarging endometriomas [2,3] but it may have side effect on
ovarian reserve. Dienogest (DNG) is an orally-active semisynthetic,
steroidal progestogen, highly selective for progesterone receptors,
derivative of 19-nortestosterone, that has recently been introduced
for the treatment of endometriosis. Clinical studies of DNG with
durations between 12 and 24 weeks have provided information on
optimal dosing and on efficacy and safety characteristics that are
relevant to the long-term management of endometriosis [4-6].
However, there are few studies that show a long term treatment over
53 weeks [7]. An over 90 weeks treatment with DNG 2mg per day in
our case report resulted in a remarkable regression of endometrioma
and elimination of symptoms.