Recurrent spontaneous miscarriage is defined as three or more consecutive pregnancy losses within 20 weeks of gestation. The etiology of this disorder remains unsolved in nearly 50% of these cases.1 An unsupportive endometrium, leading to abnormal implantation, is considered to be a key factor contributing to idiopathic recurrent spontaneous miscarriage (IRSM). Structural and functional modifications of the endometrial vasculature are essential for endometrial receptivity during the implantation window.2–4 Uterine perfusion is one of the major factors regulating uterinereceptivity and is of great importance in achieving a
normal pregnancy.5 Increased uterine artery vascular resistance and reduced uterine blood flow have been used as predictors of high-risk pregnancies, which also may be the likely causes of IRSM.

Recurrent spontaneous miscarriage is defined as three or more consecutive pregnancy losses within 20 weeks of gestation. The etiology of this disorder remains unsolved in nearly 50% of these cases.1 An unsupportive endometrium, leading to abnormal implantation, is considered to be a key factor contributing to idiopathic recurrent spontaneous miscarriage (IRSM). Structural and functional modifications of the endometrial vasculature are essential for endometrial receptivity during the implantation window.2–4 Uterine perfusion is one of the major factors regulating uterinereceptivity and is of great importance in achieving a
normal pregnancy.5 Increased uterine artery vascular resistance and reduced uterine blood flow have been used as predictors of high-risk pregnancies, which also may be the likely causes of IRSM.